Glutathione Reduced – You Cannot Survive With Reduced Glutathione
Reduced glutathione is commonly referred to as glutathione or GSH. It is a water soluble compound that occurs in all the cells in the body.
It is so important to each and every cell that its absence or depletion in its level will result in death of the cell.
Besides being a powerful antioxidant, the effects of glutathione is it’s associated with many cellular functions which include detoxification, transport of amino acids, production of co-enzymes and keeping vitamins A and E in active (or reduced) state.
Reduced Glutathione – An Electron Donor (Antioxidant)
Reduced glutathione antioxidant has a high capacity to donate an electron (chemically known as reodox potential). When present in high concentration, this power is amplified into its renowned anti oxidation potential.
This potential is hampered if the levels of glutathione reduced GSH inside and outside the cells are compromised (normal levels disturbed for any reason).
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In the process of anti oxidation, it sacrifices itself by giving away its electrons to neutralize the potential harmful effect of free radicals. It is then known as oxidized glutathione.
An enzyme called glutathione reductase (GSR) reverses the oxidized state of glutathione to the reduced state thereby restoring its power to continue functioning as an antioxidant.
Composition of Glutathione
Oxidative Stress - Reduced Glutathione
Glutathione is made up of L-cysteine, L-glutamine and glycine (all amino acids). L-cysteine is primarily responsible for the powerful anti oxidizing potential (chemically, strong electron donating character) of glutathione GSH. Elsewhere, it is found in plasma in much lower levels.
Glutathione in the Body
Comparatively higher levels of glutathione are found in the liver, spleen, kidney, lens (eyes), erythrocytes, and white blood cells (leukocytes).
Reduced Glutathione –the Martyr
As seen above, reduced glutathione sacrifices itself during anti-oxidation process. Like any other compounds in the body, glutathione levels also come under stress when exposed excessively to sunlight (UV and other radiations), viral infections, environmental pollutants, heavy metals (generally from polluted food and water), pesticides, dietary deficiencies of glutathione precursors.
This can happen because the rate of production of glutathione by the body from nutritional sources reaches a level lower than the rate at which the glutathione is being used up in fighting (reducing) the free radicals.
It is at times like these that you need to replenish the levels from outside, e.g. through food or glutathione supplement, transdermal absorptions, etc. Its always advised that a person seek the advice from a medical professional before taking any natural supplement.
Why Glutathione reduced levels are dangerous to Our Health by Dr. Nagasawa
Role of Glutathione
Prolonged depleted levels of reduced glutathione are ultimately manifested in the form of aging –skin wrinkles, fatigue, inability to withstand strain, etc. Age in terms of years has no relevance to this manifestation. This perhaps explains why many persons look so young despite being old (of advanced ages).
- As a cell protectant, reduced glutathione automatically becomes protector of tissues like skin, lens, cornea, and retina against radiation damage.
- It also is responsible for detoxification processes in the liver, kidneys, lungs, intestinal epithelia, and other organs.
- It keeps other enzymes in reduced state (i.e. ready to act).
- It is involved in synthesis of neurotransmitters.
Your glutathione levels, including reduced glutathione in the body, is a good indicator of the health of the cells.
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